Treatment of Wegener's granulomatosis with intravenous immunoglobulin

C Richter; A Schnabel; E Csernok; E Reinhold-Keller; W L Gross

doi:10.1007/978-1-4757-9182-2_88

Treatment of Wegener's granulomatosis with intravenous immunoglobulin

Adv Exp Med Biol. 1993:336:487-9. doi: 10.1007/978-1-4757-9182-2_88.

Authors

C Richter¹, A Schnabel, E Csernok, E Reinhold-Keller, W L Gross

Affiliation

¹ Dept. of Rheumatology, Medical University of Lübeck, Germany.

PMID: 8296662
DOI: 10.1007/978-1-4757-9182-2_88

Abstract

We report about the treatment of eight patients with Wegener's granulomatosis and one patient with systemic pANCA-associated vasculitis with a single course of high-dose intravenous immunoglobulin (IVIG). In 5 of 9 patients (55%) this resulted in significant clinical improvement, in two patients a decrease of the ANCA-titre was seen.

MeSH terms

Adult
Antibodies, Antineutrophil Cytoplasmic
Autoantibodies / blood
Autoantibodies / immunology
Granulomatosis with Polyangiitis / immunology
Granulomatosis with Polyangiitis / therapy*
Humans
Immunoglobulin G / blood
Immunoglobulin G / immunology
Immunoglobulins, Intravenous / administration & dosage
Immunoglobulins, Intravenous / therapeutic use*
Middle Aged
Myeloblastin
Serine Endopeptidases / immunology
Vasculitis / immunology
Vasculitis / therapy

Substances

Antibodies, Antineutrophil Cytoplasmic
Autoantibodies
Immunoglobulin G
Immunoglobulins, Intravenous
Serine Endopeptidases
Myeloblastin