Abstract
A novel approach is described for the treatment of IgE-mediated allergic reactions which is based on the induction of a strong anti-IgE response in the host. Vaccination of ovalbumin-sensitized rats with constant domains two and three of rat IgE coupled to a heterologous carrier protein resulted in a profound decrease in serum levels of IgE, and later in a nearly complete block of histamine release from mast cells and basophils upon challenge with either a cross-linking polyclonal anti-IgE antiserum or a specific allergen.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Allergens / immunology*
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Animals
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Antibodies, Anti-Idiotypic / immunology
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Hypersensitivity / therapy*
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Immunoglobulin E / immunology*
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Immunoglobulin Fragments / immunology
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Immunotherapy
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Leukocyte Count
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Mast Cells / cytology
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Rats
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Rats, Inbred Strains
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Recombinant Fusion Proteins / immunology
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Skin Tests
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Vaccines, Synthetic / immunology*
Substances
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Allergens
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Antibodies, Anti-Idiotypic
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Immunoglobulin Fragments
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Recombinant Fusion Proteins
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Vaccines, Synthetic
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Immunoglobulin E