Hypercholesterolemia of copper deficiency is linked to glutathione metabolism and regulation of hepatic HMG-CoA reductase

G E Bunce

doi:10.1111/j.1753-4887.1993.tb03061.x

Hypercholesterolemia of copper deficiency is linked to glutathione metabolism and regulation of hepatic HMG-CoA reductase

Nutr Rev. 1993 Oct;51(10):305-7. doi: 10.1111/j.1753-4887.1993.tb03061.x.

Author

G E Bunce¹

Affiliation

¹ Department of Biochemistry and Nutrition, Virginia Polytechnic Institute, Blacksburg 24061.

PMID: 8302488
DOI: 10.1111/j.1753-4887.1993.tb03061.x

Abstract

Copper deficiency in rats causes hypercholesterolemia and increases in hepatic glutathione concentration and HMG-CoA reductase activity. Prevention of the increase in hepatic glutathione abolished the other changes.

Publication types

Review

MeSH terms

Animals
Copper / deficiency*
Glutathione / metabolism*
Hydroxymethylglutaryl CoA Reductases / metabolism*
Hypercholesterolemia / etiology*
Liver / enzymology
Liver / metabolism*
Rats

Substances

Copper
Hydroxymethylglutaryl CoA Reductases
Glutathione