Potentiation of 5-fluorouracil induced inhibition of thymidylate synthase in human colon tumors by leucovorin is dose dependent

Adv Exp Med Biol. 1993:338:613-6. doi: 10.1007/978-1-4615-2960-6_126.
No abstract available

MeSH terms

  • Binding Sites
  • Colonic Neoplasms / enzymology*
  • Colonic Neoplasms / pathology
  • Colonic Neoplasms / surgery
  • Colorectal Neoplasms / enzymology*
  • Colorectal Neoplasms / pathology
  • Colorectal Neoplasms / surgery
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Fluorodeoxyuridylate / metabolism
  • Fluorouracil / pharmacology*
  • Humans
  • Kinetics
  • Leucovorin / pharmacology*
  • Thymidylate Synthase / antagonists & inhibitors*

Substances

  • Fluorodeoxyuridylate
  • Thymidylate Synthase
  • Leucovorin
  • Fluorouracil