Folate metabolites as modulators of antitumor drug activity

Adv Exp Med Biol. 1993:338:693-8. doi: 10.1007/978-1-4615-2960-6_143.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Biological Transport
  • Biotransformation
  • Cell Line
  • Colorectal Neoplasms / drug therapy
  • Female
  • Fluorouracil / administration & dosage
  • Fluorouracil / therapeutic use
  • Folic Acid / blood
  • Folic Acid / metabolism*
  • Humans
  • Leucovorin / administration & dosage
  • Leucovorin / metabolism*
  • Leucovorin / therapeutic use
  • Ovarian Neoplasms
  • Tetrahydrofolates / administration & dosage
  • Tetrahydrofolates / metabolism
  • Tetrahydrofolates / therapeutic use
  • Tumor Cells, Cultured

Substances

  • Tetrahydrofolates
  • 5,10-methylenetetrahydrofolic acid
  • Folic Acid
  • Leucovorin
  • Fluorouracil