Abstract
We show that the null hypothesis in the Affected-Pedigree-Member (APM) method is composed of two sub-hypotheses: no linkage and correct marker allele distribution. As a result, the APM method is not robust to misspecification of marker allele frequencies.
MeSH terms
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Alleles
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Alzheimer Disease / epidemiology
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Alzheimer Disease / genetics*
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Chromosome Aberrations / epidemiology
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Chromosome Aberrations / genetics
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Chromosome Disorders
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Chromosomes, Human, Pair 19
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Gene Frequency*
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Genetic Linkage*
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Genetic Markers
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Humans
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North Carolina / epidemiology
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Pedigree
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Statistics as Topic / methods