Spontaneous rupture of splenic angiosarcoma: a case report of chemotherapeutic approach and review of the literature

Surg Today. 1993;23(4):370-4. doi: 10.1007/BF00309058.

Abstract

Angiosarcoma of the spleen is a rare disease, and the prognosis of this disease is extremely unfavorable. We herein review the case of a 45-year-old Japanese woman, who received a combined chemotherapy with cyclophosphamide, Adriamycin, vincristine, and prednisone after splenectomy and experienced a good response. The various types of chemotherapy for this disease are also discussed with references to the above case because no effective chemotherapeutic protocol for angiosarcomas has yet to be established.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Combined Modality Therapy
  • Cyclophosphamide / administration & dosage
  • Doxorubicin / administration & dosage
  • Female
  • Hemangiosarcoma / complications
  • Hemangiosarcoma / drug therapy*
  • Hemangiosarcoma / pathology
  • Hemangiosarcoma / surgery
  • Humans
  • Middle Aged
  • Neoplasm Metastasis
  • Postoperative Care
  • Prednisone / administration & dosage
  • Rupture, Spontaneous
  • Splenectomy
  • Splenic Neoplasms / complications
  • Splenic Neoplasms / drug therapy*
  • Splenic Neoplasms / pathology
  • Splenic Neoplasms / surgery
  • Splenic Rupture / drug therapy*
  • Splenic Rupture / etiology
  • Splenic Rupture / pathology
  • Splenic Rupture / surgery
  • Vincristine / administration & dosage

Substances

  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone