Abstract
A preliminary characterization of the immunomodulatory activity of isoprinosine in mice was conducted in both normal and tumor-bearing mice. Under the experimental conditions employed, isoprinosine given ip and orally was found to possess some immunomodulatory capacity in various model systems. The compound appeared to preferentially influence T- but not B-cell responses; it did not apparently influence the functional capacity of macrophages, K cells, and NK cells.
MeSH terms
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Animals
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Antigens, Neoplasm / administration & dosage
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Antineoplastic Agents / administration & dosage
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B-Lymphocytes / immunology
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Female
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Immunity / drug effects*
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Inosine / analogs & derivatives*
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Inosine Pranobex / pharmacology*
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Killer Cells, Natural / immunology
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Leukemia L1210 / immunology
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Leukemia L1210 / therapy*
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Lymphocyte Activation / drug effects
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Macrophages / immunology
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Mice
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Mice, Inbred Strains
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T-Lymphocytes / immunology
Substances
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Antigens, Neoplasm
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Antineoplastic Agents
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Inosine
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Inosine Pranobex