Implants made of glass-ceramic containing apatite and wollastonite were used for reconstruction of large bone defects of the weight-bearing acetabulum in canine total hip arthroplasties. 24 dogs underwent replacements and were killed after 3, 6, and 12 months. The interface between the prosthesis and bone was examined radiographically, histologically, and mechanically. Bone bonding with the prosthesis occurred in all the implants. Glass ceramic containing apatite and wollastonite implants seem promising for use in total hip arthroplasty as filling materials for large defects in weight-bearing bone.