Synthesis of N-[tris[2-[[N-(benzyloxy)amino]carbonyl]ethyl]methyl]succinamic acid, trisuccin. Hydroxamic acid derivatives as a new class of bifunctional chelating agents

A Safavy; D J Buchsbaum; M B Khazaeli

doi:10.1021/bc00021a002

Synthesis of N-[tris[2-[[N-(benzyloxy)amino]carbonyl]ethyl]methyl]succinamic acid, trisuccin. Hydroxamic acid derivatives as a new class of bifunctional chelating agents

Bioconjug Chem. 1993 May-Jun;4(3):194-8. doi: 10.1021/bc00021a002.

Authors

A Safavy¹, D J Buchsbaum, M B Khazaeli

Affiliation

¹ Department of Radiation Oncology, University of Alabama, Birmingham 35233.

PMID: 8324008
DOI: 10.1021/bc00021a002

Abstract

In an effort to generate bifunctional chelating agents (BCAs) with improved labeling, conjugation, and biodistribution properties, the synthesis of trisuccin is reported. This new hydroxamate BCA, after synthesis and characterization, was used for conjugation and radiolabeling of monoclonal antibodies with 99mTc. This new class of synthetic BCAs may be useful in the radioimmunodiagnosis and radioimmunotherapy of cancer.

MeSH terms

Antibodies, Monoclonal
Chelating Agents / chemical synthesis*
Chelating Agents / chemistry
Chromatography, Thin Layer
Cross-Linking Reagents / chemical synthesis*
Cross-Linking Reagents / chemistry
Hydroxamic Acids / chemical synthesis*
Hydroxamic Acids / chemistry
Immunotoxins / chemistry
Isotope Labeling / methods
Magnetic Resonance Spectroscopy
Succinates / chemical synthesis*
Succinates / chemistry
Technetium / chemistry

Substances

Antibodies, Monoclonal
Chelating Agents
Cross-Linking Reagents
Hydroxamic Acids
Immunotoxins
Succinates
trisuccin
Technetium