Enhanced incorporation of 1-beta-D-arabinofuranosylcytosine by pretreatment with etoposide

Cancer Invest. 1993;11(4):388-92. doi: 10.3109/07357909309018870.

Abstract

We examined the effects of timing of administration of etoposide on cytosine arabinoside (ara-C) incorporation into DNA in L1210 ascites tumor. At 1 hr after injection of ara-C, 3-hr and 6-hr pretreatments with 15 mg/kg of etoposide increased ara-C incorporation to more than 200% as compared to that of ara-C given alone. Simultaneous administration of etoposide, however, decreased ara-C incorporation to 33% of that of ara-C alone. These results might explain the previously reported sequence dependency of the antitumor effect of etoposide and ara-C.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Combined Chemotherapy Protocols / pharmacology
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Cytarabine / administration & dosage*
  • Cytarabine / pharmacology
  • DNA, Neoplasm / drug effects
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Etoposide / administration & dosage*
  • Etoposide / pharmacology
  • Leukemia L1210 / drug therapy*
  • Male
  • Mice
  • Mice, Inbred Strains

Substances

  • DNA, Neoplasm
  • Cytarabine
  • Etoposide