Studies on annelated 1,4-benzothiazines and 1,5-benzothiazepines. VI. Synthesis and preliminary pharmacological evaluation of 1-alkylaminomethyl-4,5-dihydro-s-triazolo[3,4-d]-1,5-benzothiazepines

V Ambrogi; G Grandolini; L Perioli; A Giampietri

Studies on annelated 1,4-benzothiazines and 1,5-benzothiazepines. VI. Synthesis and preliminary pharmacological evaluation of 1-alkylaminomethyl-4,5-dihydro-s-triazolo[3,4-d]-1,5-benzothiazepines

Farmaco. 1993 May;48(5):653-64.

Authors

V Ambrogi¹, G Grandolini, L Perioli, A Giampietri

Affiliation

¹ Istituto di Chimica Farmaceutica e Tecnica Farmaceutica, Università degli Studi di Perugia, Italy.

PMID: 8343212

Abstract

A series of new 1-alkylaminomethyl derivatives of 4,5-dihydro-s- triazolo[3,4-d]-1,5-benzothiazepines has been prepared using chloromethyltriazolobenzothiazepines 4a-g as key intermediates. The 1-alkylaminomethyl derivatives were tested for CNS activity on mice and some of them caused remarkable decrease of spontaneous motor activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antidepressive Agents, Tricyclic / chemical synthesis*
Antidepressive Agents, Tricyclic / chemistry
Antidepressive Agents, Tricyclic / pharmacology
Lethal Dose 50
Mice
Motor Activity / drug effects
Structure-Activity Relationship
Thiazepines / chemical synthesis*
Thiazepines / chemistry
Thiazepines / pharmacology
Triazoles / chemical synthesis*
Triazoles / chemistry
Triazoles / pharmacology

Substances

Antidepressive Agents, Tricyclic
Thiazepines
Triazoles