In the submitted paper the authors describe in detail the administration of cultivated epidermal autotransplants (CEA in a patient with severe burns (80% of the body surface). They draw attention to several problems which occurred during treatment: a) a relatively small overall increase of CEA and the long time required for their cultivation, b) the very difficult preparation of infected wound surfaces for transplantation, c) secondary healing of CEA. The solution of these problems is according to the authors optimization of the laboratory technique of CEA cultivation and substitution of the dermal component of skin.