Critical examination of an enzyme immunoassay for detection of positive IgM antibodies against toxoplasma in newborns

Zentralbl Bakteriol. 1993 Jun;278(4):566-9. doi: 10.1016/s0934-8840(11)80828-5.

Abstract

The Toxonostika IgM test, which has been examined in this study, is a modified antibody capture test (7). Evaluation with sera from newborns revealed that, like in the ELISA tested in 1988, doubtful or false positive results were obtained in 10% of the cases (6). Therefore, a positive toxoplasmosis IgM result in newborn sera should always be retested with another test system.

Publication types

  • Clinical Trial

MeSH terms

  • Animals
  • Antibodies, Protozoan / analysis*
  • Antibodies, Protozoan / immunology
  • Enzyme-Linked Immunosorbent Assay*
  • False Positive Reactions
  • Humans
  • Immunoglobulin M / analysis*
  • Immunoglobulin M / immunology
  • Infant, Newborn
  • Toxoplasma / immunology*
  • Toxoplasmosis / diagnosis*

Substances

  • Antibodies, Protozoan
  • Immunoglobulin M