N-substituted 4-carboxy-1-phenyl-1H-pyrazole-5-propanamides with antiinflammatory, analgesic, antipyretic and platelet antiaggregating activities

G Menozzi; L Mosti; P Schenone; M D'Amico; C Falzarano; F Rossi

N-substituted 4-carboxy-1-phenyl-1H-pyrazole-5-propanamides with antiinflammatory, analgesic, antipyretic and platelet antiaggregating activities

Farmaco. 1993 Apr;48(4):539-49.

Authors

G Menozzi¹, L Mosti, P Schenone, M D'Amico, C Falzarano, F Rossi

Affiliation

¹ Istituto di Scienze Farmaceutiche dell'Università Viale Benedetto XV, Genova, Italy.

PMID: 8357469

Abstract

The synthesis of a series of N-substituted 4-carboxy-1-phenyl-1H-pyrazole-5-propanamides by reaction of 1-phenyl-1H-oxepino[4,3-c]pyrazole-4(8H),6(7H)-dione with aromatic primary amines is described. Some amides showed a platelet antiaggregating activity in vitro superior or comparable to that of acetylsalicylic acid, as well as moderate antiinflammatory, analgesic and antipyretic activities in rats or mice.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amides / chemical synthesis*
Amides / pharmacology
Animals
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
Body Temperature / drug effects
Humans
In Vitro Techniques
Mice
Platelet Aggregation / drug effects
Platelet Aggregation Inhibitors / chemical synthesis*
Platelet Aggregation Inhibitors / pharmacology
Pyrazoles / chemical synthesis*
Pyrazoles / pharmacology
Rats

Substances

Amides
Anti-Inflammatory Agents, Non-Steroidal
Platelet Aggregation Inhibitors
Pyrazoles