Abstract
The in vitro antifungal activities of some naphthyl and thienyl derivatives of 1H-imidazol-1-yl-4-phenyl-1H-pyrrol-3-ylmethane against Candida albicans and Candida spp are reported. The title derivatives were prepared starting from proper arylstirylketones, which were reacted with tosylmethylisocyanide (Tos-MIC) to afford the related 4-phenyl-1H-pyrrol-3-yl aryl ketones. Reduction of ketones to the corresponding carbinols followed by treatment of the last compounds with 1,1'-carbonyldiimidazole (CDI) gave the title imidazoles. The related N-methylpyrrole derivatives are also described.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / pharmacology
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Candida / drug effects*
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Candida albicans / drug effects
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Imidazoles / chemical synthesis*
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Imidazoles / pharmacology
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Naphthalenes / chemical synthesis*
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Naphthalenes / pharmacology
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Spectrophotometry, Infrared
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Structure-Activity Relationship
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Thiophenes / chemical synthesis*
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Thiophenes / pharmacology
Substances
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Antifungal Agents
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Imidazoles
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Naphthalenes
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Thiophenes
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2-thienyl-1H-imidazol-1-yl-4-phenyl-1H-pyrrol-3-ylmethane
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2-naphthyl-1H-imidazol-1-yl-4-phenyl-1-pyrrol-3-ylmethane