Orbito-ocular granulocytic sarcoma (OOGS) and acute myeloblastic leukemia (AML) with duplication of Philadelphia chromosome

Cancer Genet Cytogenet. 1993 Aug;69(1):38-40. doi: 10.1016/0165-4608(93)90110-8.

Abstract

A 6-year-old Turkish boy with bilateral orbito-ocular granulocytic sarcoma and AML is described. Cytogenetic studies on peripheral blood disclosed an abnormal hyperdiploid population with a double Ph chromosome. Despite intensive chemotherapy, he achieved only partial remission. Repeated cytogenetic studies on bone marrow during relapse revealed the persistence of double Ph chromosome. The aggressive course and the short survival time of this patient, despite adequate chemo-radiotherapy, may be explained by the presence of the double Ph chromosome.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Child
  • Combined Modality Therapy
  • Cytarabine / administration & dosage
  • Dexamethasone / administration & dosage
  • Doxorubicin / administration & dosage
  • Etoposide / administration & dosage
  • Eye Neoplasms / drug therapy
  • Eye Neoplasms / genetics*
  • Eye Neoplasms / radiotherapy
  • Humans
  • Karyotyping
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / radiotherapy
  • Leukemia, Myeloid, Acute / drug therapy
  • Leukemia, Myeloid, Acute / genetics*
  • Leukemia, Myeloid, Acute / radiotherapy
  • Male
  • Methotrexate / administration & dosage
  • Multigene Family
  • Neoplasms, Multiple Primary / drug therapy
  • Neoplasms, Multiple Primary / genetics*
  • Neoplasms, Multiple Primary / radiotherapy
  • Orbital Neoplasms / drug therapy
  • Orbital Neoplasms / genetics*
  • Orbital Neoplasms / radiotherapy
  • Philadelphia Chromosome*
  • Thioguanine / administration & dosage

Substances

  • Cytarabine
  • Etoposide
  • Dexamethasone
  • Doxorubicin
  • Thioguanine
  • Methotrexate