[Liver damage during administration of itraconazole (Trisporal)]

A P Lavrijsen; K J Balmus; W M Nugteren-Huying; A C Roldaan; J W van 't Wout; B H Stricker

[Liver damage during administration of itraconazole (Trisporal)]

Ned Tijdschr Geneeskd. 1993 Jan 2;137(1):38-41.

[Article in Dutch]

Authors

A P Lavrijsen¹, K J Balmus, W M Nugteren-Huying, A C Roldaan, J W van 't Wout, B H Stricker

Affiliation

¹ Academisch Ziekenhuis, afd. Dermatologie, Leiden.

PMID: 8380490

Abstract

Three case histories are described of patients, two women aged 62 and 57 and a man aged 75 years, who developed symptomatic hepatic injury five to six weeks after starting itraconazole treatment. In two of them the biochemical pattern of liver injury was cholestatic. Other causes of hepatic injury were excluded. Monitoring serum liver enzymes is advisable in patients treated with itraconazole for one month or longer.

Publication types

Case Reports

MeSH terms

Aged
Antifungal Agents / adverse effects*
Aspergillosis, Allergic Bronchopulmonary / drug therapy
Chemical and Drug Induced Liver Injury / blood
Chemical and Drug Induced Liver Injury / etiology*
Female
Humans
Itraconazole
Ketoconazole / adverse effects
Ketoconazole / analogs & derivatives*
Ketoconazole / therapeutic use
Liver Function Tests
Male
Middle Aged
Onychomycosis / drug therapy

Substances

Antifungal Agents
Itraconazole
Ketoconazole