Abstract
Scatter factor (SF), a cell motility factor with a multimodular structure, is identical to hepatocyte growth factor (HGF), a potent mitogen of various cell types. The receptor for SF/HGF has recently been identified as the c-Met proto-oncogene product, a transmembrane receptor tyrosine kinase. Depending on the target cells and culture conditions, SF/HGF has several distinct activities in vitro, i.e., it induces cell motility, proliferation, invasiveness, tubular morphogenesis, angiogenesis, or cytotoxicity. In vivo, SF/HGF might be involved in tissue regeneration, tumor progression, and embryological processes.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Chromosome Banding
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Chromosomes, Human, Pair 7*
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Hepatocyte Growth Factor / genetics
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Hepatocyte Growth Factor / physiology*
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Humans
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Molecular Sequence Data
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Protein-Tyrosine Kinases / genetics
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Protein-Tyrosine Kinases / physiology*
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Proto-Oncogene Mas
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins / physiology*
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Proto-Oncogene Proteins c-met
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Proto-Oncogenes
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Receptors, Cell Surface / genetics
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Receptors, Cell Surface / physiology*
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Sequence Homology, Amino Acid
Substances
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MAS1 protein, human
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Proto-Oncogene Mas
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Proto-Oncogene Proteins
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Receptors, Cell Surface
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Hepatocyte Growth Factor
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Protein-Tyrosine Kinases
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Proto-Oncogene Proteins c-met