Turning behavior induced in mice by a neurokinin A receptor agonist: stereoselective blockade by SR 48968, a non-peptide receptor antagonist

Neurosci Lett. 1993 Jan 4;149(1):40-2. doi: 10.1016/0304-3940(93)90342-i.

Abstract

The intrastriatal injection of [Nle10]-NKA(4-10), a neurokinin A agonist, (0.05-5 ng/mouse) elicited vigorous contralateral rotations. This behavior was dose-dependently antagonized by SR 48968 (ED50: 0.15 mg/kg i.p.: 0.19 mg/kg p.o.), a selective non-peptide antagonist of NK-2 receptors, but it was not affected by spiroperidol. This suggests that NK-2 receptor stimulation may affect the activity of the striatum without necessarily involving dopaminergic systems.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects*
  • Benzamides / pharmacology*
  • Corpus Striatum
  • Dopamine D2 Receptor Antagonists
  • Dose-Response Relationship, Drug
  • Female
  • Injections
  • Injections, Intraperitoneal
  • Mice
  • Mice, Inbred Strains
  • Neurokinin A / analogs & derivatives*
  • Neurokinin A / pharmacology
  • Peptide Fragments / pharmacology*
  • Piperidines / pharmacology*
  • Receptors, Neurokinin-2
  • Receptors, Neurotransmitter / physiology*
  • Spiperone / pharmacology
  • Stereoisomerism
  • Stereotyped Behavior / drug effects*
  • Stereotyped Behavior / physiology*

Substances

  • Benzamides
  • Dopamine D2 Receptor Antagonists
  • Peptide Fragments
  • Piperidines
  • Receptors, Neurokinin-2
  • Receptors, Neurotransmitter
  • neurokinin A (4-10), Nle(10)-
  • Spiperone
  • SR 48968
  • Neurokinin A