Abstract
Small resistance arteries were isolated from human subcutaneous fat and omentum and studied using a myograph. Endothelin-1 induced a concentration-dependent contraction in both type of arteries. In subcutaneous arteries preincubation with calcium antagonists partially inhibited responses to endothelin-1. The effectiveness of the calcium antagonists was nisoldipine > nimodipine > verapamil = flunarizine > diltiazem. In omental arteries nimodipine and diltiazem had no significant effect on endothelin-1-induced contraction and removal of extracellular calcium also had little effect on responses to endothelin-1. The role of influx of extracellular calcium through voltage operated calcium channels in endothelin-1-induced contraction appear to differ between subcutaneous and omental resistance arteries.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adipose Tissue / blood supply*
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Adult
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Aged
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Arteries / drug effects
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Arteries / physiology*
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Calcium Channel Blockers / pharmacology*
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Calcium Channels / physiology
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Diltiazem / pharmacology
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Endothelins / pharmacology*
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Flunarizine / pharmacology
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Humans
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Membrane Potentials / drug effects
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Membrane Potentials / physiology
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Middle Aged
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Muscle Contraction / drug effects
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Muscle Contraction / physiology
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Muscle, Smooth, Vascular / drug effects
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Muscle, Smooth, Vascular / physiology
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Myography
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Nimodipine / pharmacology
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Nisoldipine / pharmacology
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Omentum / blood supply*
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Vasoconstriction / drug effects
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Vasoconstriction / physiology*
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Verapamil / pharmacology
Substances
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Calcium Channel Blockers
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Calcium Channels
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Endothelins
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Nisoldipine
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Nimodipine
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Verapamil
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Diltiazem
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Flunarizine