Abstract
The presence of synaptic proteins involved in excitation/secretion coupling was examined in ten small cell lung cancer lines. N-Type calcium channels (omega-conotoxin receptors), synaptotagmin (p65) and syntaxin (HPC-1) were detected in eight. Co-immunoprecipitation experiments indicated that syntaxin can form a complex with synaptotagmin and calcium channels. The expression of synaptotagmin in small cell lung cancer may elicit an autoimmune response that reduces transmitter release at the nerve terminal.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Monoclonal
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Antigens, Surface / analysis
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Antigens, Surface / metabolism*
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Blotting, Western
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Calcium Channels / metabolism*
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Calcium-Binding Proteins*
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Carcinoma, Small Cell / metabolism*
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Cholic Acids
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Humans
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Immunosorbent Techniques
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Lung Neoplasms / metabolism*
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Membrane Glycoproteins / analysis
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Membrane Glycoproteins / metabolism*
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Nerve Tissue Proteins / analysis
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Nerve Tissue Proteins / metabolism*
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Peptides / metabolism
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Peptides / pharmacology
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Rats
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Synaptotagmin I
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Synaptotagmins
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Syntaxin 1
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Tumor Cells, Cultured
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omega-Conotoxin GVIA
Substances
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Antibodies, Monoclonal
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Antigens, Surface
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Calcium Channels
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Calcium-Binding Proteins
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Cholic Acids
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Membrane Glycoproteins
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Nerve Tissue Proteins
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Peptides
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STX1A protein, human
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Stx1a protein, rat
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Synaptotagmin I
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Syntaxin 1
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Synaptotagmins
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omega-Conotoxin GVIA
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3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate