(3SR,4aRS,6RS,8aRS)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3 - carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist

J Med Chem. 1993 Jul 9;36(14):2046-8. doi: 10.1021/jm00066a016.
No abstract available

MeSH terms

  • Animals
  • Excitatory Amino Acid Antagonists*
  • Isoquinolines / chemical synthesis*
  • Isoquinolines / chemistry
  • Isoquinolines / pharmacology*
  • Mice
  • Receptors, AMPA
  • Stereoisomerism
  • Structure-Activity Relationship
  • Tetrazoles / chemical synthesis*
  • Tetrazoles / chemistry
  • Tetrazoles / pharmacology*

Substances

  • Excitatory Amino Acid Antagonists
  • Isoquinolines
  • Receptors, AMPA
  • Tetrazoles
  • tezampanel