Delaminomycins, novel nonpeptide extracellular matrix receptor antagonist and a new class of potent immunomodulator. II. Physico-chemical properties and structure elucidation of delaminomycin A

M Ueno; T Someno; R Sawa; H Iinuma; H Naganawa; M Ishizuka; T Takeuchi

doi:10.7164/antibiotics.46.979

Delaminomycins, novel nonpeptide extracellular matrix receptor antagonist and a new class of potent immunomodulator. II. Physico-chemical properties and structure elucidation of delaminomycin A

J Antibiot (Tokyo). 1993 Jun;46(6):979-84. doi: 10.7164/antibiotics.46.979.

Authors

M Ueno¹, T Someno, R Sawa, H Iinuma, H Naganawa, M Ishizuka, T Takeuchi

Affiliation

¹ Institute for Chemotherapy, Microbial Chemistry Research Foundation, Shizuoka, Japan.

PMID: 8393852
DOI: 10.7164/antibiotics.46.979

Abstract

Delaminomycins, novel extracellular matrix receptor antagonists, have been isolated from a culture broth of Streptomyces albulus MJ202-72F3. The structure of delaminomycin A was determined to be 3-[[2-[(3E,5E)-2,8-dihydroxy-7-methyl-3,5-decadienyl]- 1,6,8- trimethyl-1,2,4a,5,6,7,8,8a-octahydro-1-naphthyl]carbonyl]-5- hydroxypyrrolidine-2,4-dione by analyses of spectral properties and chemical studies.

MeSH terms

Adjuvants, Immunologic / chemistry*
Adjuvants, Immunologic / pharmacology*
Magnetic Resonance Spectroscopy
Pyrrolidinones / chemistry*
Pyrrolidinones / pharmacology*
Receptors, Cell Surface / antagonists & inhibitors*
Streptomyces / chemistry*
Tetrahydronaphthalenes / chemistry*
Tetrahydronaphthalenes / pharmacology*

Substances

Adjuvants, Immunologic
Pyrrolidinones
Receptors, Cell Surface
Tetrahydronaphthalenes
extracellular matrix receptor
delaminomycin A