[Prevention of postoperative recurrence after hepatic resection for metastatic colorectal cancer by adjuvant locoregional chemotherapy]

Gan To Kagaku Ryoho. 1993 Aug;20(11):1535-7.
[Article in Japanese]

Abstract

Postoperative adjuvant locoregional chemotherapy was performed on patients who underwent hepatic resection for metastatic colorectal cancer. To prevent recurrence in the residual liver after hepatic resection. 7 patients received intra-hepato-arterial infusion of MMC, 5-fluorouracil (5-FU), doxorubicin + Lipiodol emulsion. Sixteen cases did not receive such treatment. The 1-, 2- and 3-year cumulative disease free rates were 100, 80 and 40% in the patients with this adjuvant chemotherapy, against 61.4, 54.6 and 28.1% in those without this locoregional therapy, respectively. The 1-, 2- and 3-year cumulative survival rates were 100, 100 and 60% in the TAI-E group, and 73.7, 63.3 and 63.3% in the patients without TAI-E, respectively. Postoperative adjuvant locoregional chemotherapy is considered effective to prevent the recurrence of metastatic colorectal cancer in the residual liver after hepatectomy.

Publication types

  • English Abstract

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
  • Chemoembolization, Therapeutic*
  • Chemotherapy, Adjuvant
  • Colorectal Neoplasms / pathology*
  • Doxorubicin / administration & dosage
  • Female
  • Hepatectomy*
  • Humans
  • Infusions, Intra-Arterial
  • Iodized Oil / administration & dosage
  • Liver Neoplasms / prevention & control*
  • Liver Neoplasms / secondary
  • Liver Neoplasms / surgery
  • Male
  • Middle Aged
  • Mitomycin / administration & dosage
  • Neoplasm Recurrence, Local / prevention & control*
  • Postoperative Care

Substances

  • Mitomycin
  • Iodized Oil
  • Doxorubicin