Trisomy 13 in a patient with leukemic progression of myelodysplasia

L Luciano; P Polito; L Catalano; C Selleri; F Alfinito; B Rotoli

doi:10.1016/0165-4608(93)90090-9

Trisomy 13 in a patient with leukemic progression of myelodysplasia

Cancer Genet Cytogenet. 1993 Sep;69(2):136-8. doi: 10.1016/0165-4608(93)90090-9.

Authors

L Luciano¹, P Polito, L Catalano, C Selleri, F Alfinito, B Rotoli

Affiliation

¹ Hematology Division, Federico II University of Naples Medical School, Italy.

PMID: 8402552
DOI: 10.1016/0165-4608(93)90090-9

Abstract

Four months after the diagnosis of refractory anemia, a 60-year-old patient developed acute leukemia with blast cells that were poorly differentiated by morphology and clearly myeloid by immunophenotyping. Cytogenetic analysis performed at leukemization showed trisomy 13. An extra copy of chromosome 13 has already been reported in a few cases of acute leukemia and myelodysplastic syndrome.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Anemia, Refractory / complications
Bone Marrow / pathology
Chromosome Banding
Chromosomes, Human, Pair 13*
Female
Humans
Immunophenotyping
Karyotyping
Leukemia, Myeloid, Acute / complications*
Middle Aged
Myelodysplastic Syndromes / genetics*
Myelodysplastic Syndromes / immunology
Myelodysplastic Syndromes / pathology
Trisomy*