Abstract
Two novel tropoloisoquinoline alkaloids, Pareirubrines A and B, have been isolated as antileukemic substances from Cissampelos pareira (Menispermaceae), together with the same skeleton alkaloids, grandirubrine and isoimerubrine. Their structures were elucidated by nuclear magnetic resonance (NMR) studies, and their solid state tautomeric forms were examined by X-ray crystallographic analysis.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Crystallography, X-Ray
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Isoquinolines / isolation & purification*
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Isoquinolines / pharmacology
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Leukemia P388 / drug therapy
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Magnetic Resonance Spectroscopy
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Mice
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Phorbols
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Stereoisomerism
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Tropolone / analogs & derivatives*
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Tropolone / isolation & purification
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Tropolone / pharmacology
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Tumor Cells, Cultured / drug effects
Substances
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Antineoplastic Agents, Phytogenic
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Isoquinolines
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Phorbols
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pareirubrine A
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pareirubrine B
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Tropolone