Abstract
A new methodology for chemical differentiation of one amino and four hydroxyl groups of D-galactosamine derivatives and its application for the synthesis of D-galactosamine-4-phosphate analogs of lipid A are described. Preliminary examination of biological activity revealed that the synthetic monosaccharides show mitogenic activity.
MeSH terms
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Galactosamine / analogs & derivatives*
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Galactosamine / chemical synthesis
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Galactosamine / chemistry
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Galactosamine / pharmacology
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Galactosephosphates / chemical synthesis*
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Galactosephosphates / chemistry
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Galactosephosphates / pharmacology
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Lipid A / analogs & derivatives*
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Lipid A / pharmacology
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Mitogens / chemical synthesis*
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Mitogens / pharmacology
Substances
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Galactosephosphates
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Lipid A
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Mitogens
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galactosamine-4-phosphate
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Galactosamine