Abstract
In cynomolgus monkeys, we compared two human-derived SIVmac251 whole virus vaccines, a long vs short immunization schedule, and two different challenge viruses. Both vaccines induced protection after challenge with human-derived SIVmac251/32H. There was no difference between the two schedules of immunization. Seven monkeys, five of which were protected following the first challenge, were reboosted and rechallenged with monkey-derived SIVmac251, but no protection was observed. The titers of anti-human cell or -SIV neutralizing antibodies were not related to protection.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Viral / biosynthesis
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Base Sequence
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Cell Line
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DNA, Viral / genetics
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Female
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Humans
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Immunization Schedule
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In Vitro Techniques
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Macaca fascicularis
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Male
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Molecular Sequence Data
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Neutralization Tests
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Pregnancy
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Proviruses / genetics
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Simian Acquired Immunodeficiency Syndrome / immunology
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Simian Acquired Immunodeficiency Syndrome / prevention & control*
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Simian Immunodeficiency Virus / genetics
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Simian Immunodeficiency Virus / growth & development
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Simian Immunodeficiency Virus / immunology*
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Vaccines, Inactivated / isolation & purification
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Vaccines, Inactivated / pharmacology
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Viral Vaccines / isolation & purification
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Viral Vaccines / pharmacology*
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Virus Cultivation
Substances
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Antibodies, Viral
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DNA, Viral
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Vaccines, Inactivated
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Viral Vaccines