Abstract
A gene essential for the secretion of cholera toxin from the periplasm of Vibrio cholerae into the extracellular medium has been isolated and its nucleotide sequence determined. It encodes a cytoplasmic protein of 56 kDa that exhibits a high degree of similarity to gene products required for extracellular protein secretion in several other Gram- organisms. Sequence similarities in its potential ATP-binding site suggest that the protein may act as an energy provider or signal transducer in the process of extracellular secretion.
MeSH terms
-
Amino Acid Sequence
-
Bacterial Proteins / genetics*
-
Bacterial Proteins / metabolism
-
Base Sequence
-
Cell Membrane / metabolism*
-
Cholera Toxin / genetics*
-
Cholera Toxin / metabolism
-
DNA, Bacterial
-
Gene Library
-
Genes, Bacterial
-
Genetic Complementation Test
-
Membrane Proteins*
-
Molecular Sequence Data
-
Restriction Mapping
-
Sequence Homology, Amino Acid
-
Vibrio cholerae / genetics*
-
Vibrio cholerae / metabolism
Substances
-
Bacterial Proteins
-
DNA, Bacterial
-
EpsE protein, Vibrio cholerae
-
Membrane Proteins
-
Cholera Toxin
Associated data
-
GENBANK/L03649
-
GENBANK/L03650
-
GENBANK/L03651
-
GENBANK/L03652
-
GENBANK/L03653
-
GENBANK/L03654
-
GENBANK/M91438
-
GENBANK/M96172
-
GENBANK/X62366
-
GENBANK/X62367