This article reviews the outcome of injury of the hand in 25 patients treated at our institution by the open wound technique: wide débridement, drainage, open packing, and delayed closure. The results obtained are superior to those reported in the literature: Among the patients, 84% of the involved hands or fingers were salvaged, 64% had essentially normal hand function at the time of final follow-up, and 92% were able to return to their previous jobs. We propose that aggressive treatment by the open wound technique improves the outcome of high-pressure injection injuries of the hand.