Phase III trial comparing two low dose rates in brachytherapy of cervix carcinoma: report at two years

Int J Radiat Oncol Biol Phys. 1993 Feb 15;25(3):405-12. doi: 10.1016/0360-3016(93)90060-9.

Abstract

This Phase III randomized trial examined the effect of two low dose rates (0.73 or 0.38 Gy.h-1) on the local control, survival, relapse-free survival, complications, and secondary effects in the treatment of cervical cancers. A total of 204 Stage Ib or II cervical carcinoma patients were included between January 1985 and September 1988. Treatment consisted of uterovaginal 137Cs irradiation followed by surgery. The two groups were similar for age, tumor stage and medical or surgical history. Their brachytherapy parameters were also similar (60 Gy pear dimensions, dose to critical organs, total kerma, etc....) There were no differences in the short-term effects or therapeutic outcome. However, overall complications and side effects observed after 6 months were significantly more frequent (p < 0.01) in the higher dose rate group.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase III
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / epidemiology
  • Adenocarcinoma / mortality
  • Adenocarcinoma / radiotherapy*
  • Adult
  • Aged
  • Brachytherapy* / adverse effects
  • Carcinoma, Squamous Cell / epidemiology
  • Carcinoma, Squamous Cell / mortality
  • Carcinoma, Squamous Cell / radiotherapy*
  • Female
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Radiotherapy Dosage
  • Retrospective Studies
  • Uterine Cervical Neoplasms / epidemiology
  • Uterine Cervical Neoplasms / mortality
  • Uterine Cervical Neoplasms / radiotherapy*