Abstract
A precursor of biphenomycin A in mixed culture of Streptomyces griseorubiginosus No. 43708 with Pseudomonas maltophilia No. 1928 was isolated and characterized. The structure of the precursor, designated biphenomycin C was determined to be a peptide which is composed of biphenomycin A and arginylserine residue (Fig. 1), on the basis of chemical and spectroscopic evidence.
MeSH terms
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Anti-Bacterial Agents* / chemistry
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Anti-Bacterial Agents* / isolation & purification*
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Anti-Bacterial Agents* / pharmacology
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Antimicrobial Cationic Peptides
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Biotransformation
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Biphenyl Compounds / chemistry
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Biphenyl Compounds / isolation & purification
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Biphenyl Compounds / pharmacology
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Chromatography, High Pressure Liquid
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Chromatography, Thin Layer
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Dipeptides / metabolism
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Fermentation
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Gram-Positive Bacteria / drug effects
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Magnetic Resonance Spectroscopy
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Peptides*
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification
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Peptides, Cyclic / pharmacology
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Prodrugs / chemistry
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Prodrugs / isolation & purification*
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Prodrugs / pharmacology
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Pseudomonas / metabolism*
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Streptococcus / metabolism*
Substances
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Anti-Bacterial Agents
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Antimicrobial Cationic Peptides
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Biphenyl Compounds
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Dipeptides
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Peptides
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Peptides, Cyclic
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Prodrugs
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biphenomycin A
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biphenomycin C