Chemically engineered bispecific antibody directed at the p55 and p75 chains of the human interleukin 2 receptor: specific high-affinity cross-linking of p55/p75 complexes and high blocking effect on IL2-induced T cell proliferation

Transplant Proc. 1993 Feb;25(1 Pt 1):815-6.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / metabolism
  • Antibodies, Monoclonal / pharmacology*
  • Cell Line
  • Humans
  • Immunoglobulin Fab Fragments / metabolism
  • Immunoglobulin Fab Fragments / pharmacology
  • Immunoglobulin G / metabolism
  • Immunoglobulin G / pharmacology
  • Interleukin-2 / pharmacology*
  • Lymphocyte Activation* / drug effects
  • Macromolecular Substances
  • Muromonab-CD3 / pharmacology
  • Rats
  • Receptors, Interleukin-2 / immunology*
  • Recombinant Proteins / pharmacology
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology*

Substances

  • Antibodies, Monoclonal
  • Immunoglobulin Fab Fragments
  • Immunoglobulin G
  • Interleukin-2
  • Macromolecular Substances
  • Muromonab-CD3
  • Receptors, Interleukin-2
  • Recombinant Proteins