Abstract
Administration of diethylstilbestrol to female Sprague-Dawley rats at 10 mg/kg body weight daily by gavage for 1 year induced liver adenomas and carcinomas and pituitary adenomas. Using the 32P-postlabeling assay for DNA alterations, at 24 h after administration of a single dose of 100 mg/kg, modified bases were found.
MeSH terms
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Adenoma / chemically induced
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Adenoma / genetics*
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Animals
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Autoradiography
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Body Weight / drug effects
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Carcinoma / chemically induced
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Carcinoma / genetics*
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DNA / drug effects*
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Diethylstilbestrol / toxicity*
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Female
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Liver Neoplasms, Experimental / chemically induced
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Liver Neoplasms, Experimental / genetics*
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Pituitary Neoplasms / chemically induced
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Rats
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Rats, Sprague-Dawley
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Time Factors