Localization of the 70-kDa peroxisomal membrane protein to human 1p21-p22 and mouse 3

Genomics. 1993 Feb;15(2):412-4. doi: 10.1006/geno.1993.1076.

Abstract

The 70-kDa peroxisomal membrane protein (PXMP1) is a member of the ATP-binding cassette transporter family. In humans, mutations in this gene may be responsible for a subset of patients with Zellweger syndrome, a lethal inborn error of peroxisome assembly. The PXMP1 gene was assigned to human chromosome 1p21-p22 by in situ hybridization and its murine homologue (Pxmp-1) to chromosome 3 by interspecific backcross analysis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1*
  • DNA
  • Female
  • Genetic Markers
  • Humans
  • In Situ Hybridization, Fluorescence
  • Intracellular Membranes / chemistry*
  • Male
  • Membrane Proteins / genetics*
  • Mice
  • Mice, Inbred C57BL
  • Microbodies / chemistry*
  • Zellweger Syndrome / genetics

Substances

  • Genetic Markers
  • Membrane Proteins
  • DNA