Abstract
Scopadulcic acid B (SDB), a tetracyclic diterpenoid isolated from a medicinal plant, Scoparia dulcis L., inhibited the effects of tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro and in vivo; SDB inhibited TPA-enhanced phospholipid synthesis in cultured cells, and also suppressed the promoting effect of TPA on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene. The potency of SDB proved to be stronger than that of other natural antitumor-promoting terpenoids, such as glycyrrhetinic acid.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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9,10-Dimethyl-1,2-benzanthracene
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Animals
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Anticarcinogenic Agents / therapeutic use*
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Cells, Cultured
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Diterpenes / isolation & purification
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Diterpenes / therapeutic use*
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Female
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HeLa Cells
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Humans
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Mice
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Mice, Inbred ICR
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Phospholipids / metabolism
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Plants, Medicinal / chemistry
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Skin Neoplasms / chemically induced
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Skin Neoplasms / prevention & control*
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Tetradecanoylphorbol Acetate / pharmacology
Substances
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Anticarcinogenic Agents
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Diterpenes
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Phospholipids
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scopadulcic acid B
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9,10-Dimethyl-1,2-benzanthracene
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Tetradecanoylphorbol Acetate