Differences in the time course of the effects of oophorectomy in women on parameters of bone metabolism and interleukin-1 levels in the circulation

Bone Miner. 1993 Jan;20(1):79-85. doi: 10.1016/s0169-6009(08)80039-6.

Abstract

Interleukin-1 is a cytokine with bone-resorbing activity which is claimed to play a role in the pathogenesis of osteoporosis and of post-oophorectomy bone loss. We measured plasma levels of interleukin-1 (IL-1) in 16 women who underwent hysterectomy and bilateral oophorectomy and in 12 women with hysterectomy alone before surgery and 7, 15, 30, 45 and 60 days after surgery. Only oophorectomized patients showed a significant increase of circulating interleukin-1 levels. This increase was significant only 30 days after surgery, whereas a rise at 7 days (P < 0.001) was observed for serum calcium and hydroxyproline/creatinine and calcium/creatinine ratios. These data do not indicate a definite role of IL-1 in promoting bone resorption in estrogen-deficient women in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Bone Resorption / etiology
  • Bone Resorption / metabolism
  • Bone and Bones / metabolism*
  • Estrogens / metabolism
  • Female
  • Humans
  • Hysterectomy
  • Interleukin-1 / blood*
  • Middle Aged
  • Osteoporosis, Postmenopausal / etiology
  • Osteoporosis, Postmenopausal / metabolism
  • Ovariectomy / adverse effects*
  • Ovary / physiology
  • Time Factors

Substances

  • Estrogens
  • Interleukin-1