Trisomy 4 in acute myeloblastic and acute lymphoblastic leukemia

M Zollino; G Leone; S Sica; J Bajer; G Neri

doi:10.1016/0165-4608(93)90218-b

Trisomy 4 in acute myeloblastic and acute lymphoblastic leukemia

Cancer Genet Cytogenet. 1993 Feb;65(2):115-9. doi: 10.1016/0165-4608(93)90218-b.

Authors

M Zollino¹, G Leone, S Sica, J Bajer, G Neri

Affiliation

¹ Istituto di Genetica Medica, Facoltà di Medicina e Chirurgia A. Gemelli, Università Cattolica, Rome, Italy.

PMID: 8453596
DOI: 10.1016/0165-4608(93)90218-b

Abstract

We report three cases of trisomy 4 in acute leukemia. This alteration was detected as the sole cytogenetic abnormality in a case of FAB M4 leukemia; it occurred in association with 5q deletion in a case of M1, and concomitant with Ph chromosome and trisomy 17 in a case of L2 leukemia. The latter case represents the fourth report of trisomy 4 in acute lymphoblastic leukemia.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Chromosomes, Human, Pair 17*
Chromosomes, Human, Pair 4*
Chromosomes, Human, Pair 9
Female
Humans
Karyotyping
Leukemia, Myeloid, Acute / genetics*
Male
Middle Aged
Philadelphia Chromosome*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Translocation, Genetic
Trisomy*