D21S210: a highly polymorphic (GT)n marker closely linked to the beta-amyloid protein precursor (APP) gene

Hum Genet. 1993 Mar;91(1):87-8. doi: 10.1007/BF00230232.

Abstract

We describe a highly polymorphic (GT)n repeat with 14 alleles that is closely linked to the amyloid precursor protein (APP) gene on human chromosome 21. This marker, D21S210, will be useful for studies of linkage of disorders such as Alzheimer disease to the APP gene.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles*
  • Amyloid beta-Protein Precursor / genetics*
  • Base Sequence
  • Chromosomes, Human, Pair 21*
  • Female
  • Gene Frequency*
  • Genetic Linkage / genetics*
  • Humans
  • Male
  • Molecular Sequence Data
  • Pedigree
  • Polymorphism, Genetic / genetics*

Substances

  • Amyloid beta-Protein Precursor