Measured dose to ovaries and testes from Hodgkin's fields and determination of genetically significant dose

Int J Radiat Oncol Biol Phys. 1993 Mar 15;25(4):745-51. doi: 10.1016/0360-3016(93)90023-o.

Abstract

Purpose: To determine the genetically significant dose from therapeutic radiation exposure with Hodgkin's fields by estimating the doses to ovaries and testes.

Materials and methods: Phantom measurements were performed to verify estimated doses to ovaries and testes from Hodgkin's fields. Thermoluminescent LiF dosimeters (TLD-100) of 1 x 3 x 3 mm3 dimensions were embedded in phantoms and exposed to standard mantle and paraaortic fields using Co-60, 4 MV, 6 MV, and 10 MV photon beams.

Results: Our results show that measured doses to ovaries and testes are about two to five times higher than the corresponding graphically estimated doses for Co-60 and 4 MVX photon beams as depicted in ICRP publication 44. In addition, the measured doses to ovaries and testes are about 30% to 65% lower for 10 MV photon beams than for their corresponding Co-60 photon beams.

Conclusion: The genetically significant dose from Hodgkin's treatment (less than 0.01 mSv) adds about 4% to the genetically significant dose contribution to medical procedures and adds less than 1% to the genetically significant dose from all sources. Therefore, the consequence to society is considered to be very small. The consequences for the individual patient are, likewise, small.

MeSH terms

  • Abnormalities, Radiation-Induced / epidemiology
  • Abnormalities, Radiation-Induced / etiology*
  • Cobalt Radioisotopes / therapeutic use
  • Female
  • Hodgkin Disease / radiotherapy*
  • Humans
  • Male
  • Models, Anatomic
  • Ovary / anatomy & histology
  • Ovary / radiation effects*
  • Pregnancy
  • Pregnancy Outcome
  • Radiation
  • Radiotherapy / adverse effects*
  • Radiotherapy / methods
  • Radiotherapy Dosage
  • Testis / anatomy & histology
  • Testis / radiation effects*

Substances

  • Cobalt Radioisotopes