Linkage analysis in German breast cancer families with early onset of the disease, using highly polymorphic markers from the chromosome 17q11-q24 region

W Zimmermann; E Bender; K Rohde; A Reis; R Wiseman; A Futreal; H Krause; H Prokoph; S Werner; S Scherneck

Linkage analysis in German breast cancer families with early onset of the disease, using highly polymorphic markers from the chromosome 17q11-q24 region

Am J Hum Genet. 1993 Apr;52(4):789-91.

Authors

W Zimmermann¹, E Bender, K Rohde, A Reis, R Wiseman, A Futreal, H Krause, H Prokoph, S Werner, S Scherneck

Affiliation

¹ Tumorgenetik, Max-Delbrück-Centrum für Molekulare Medizin, Berlin-Buch, Germany.

PMID: 8460645
PMCID: PMC1682094

Abstract

Linkage analysis in German breast cancer families with early onset of the disease by using six markers on chromosome 17q11-q24 has been carried out. In the region between markers D17S250 and GH, three markers showed positive LOD scores at an estimated distance of zero. Evidence for linkage is greatest for D17S250, with a LOD score of 2.42.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Breast Neoplasms / genetics*
Cell Line, Transformed
Chromosome Mapping / methods*
Chromosomes, Human, Pair 17*
DNA, Neoplasm / analysis
Family Health
Female
Genetic Linkage
Genetic Markers
Germany
Humans
Lod Score
Lymphocytes
Middle Aged
Neoplastic Syndromes, Hereditary / genetics
Ovarian Neoplasms / genetics
Pedigree
Polymorphism, Genetic
Proto-Oncogenes*

Substances

DNA, Neoplasm
Genetic Markers