Abstract
Cloning and sequence analysis of a new open reading frame from Bacillus cereus reveals the relationship to a recently identified family of putative eukaryotic transcription activators similar to the yeast SNF2 gene product. As a result of comparative analysis of sequence features conserved in all members of this family, a gene from a chilo iridescent virus, as well as a putative helicase from Escherichia coli (hepA), can also be grouped into this family. The unexpected presence of prokaryotic and viral sequences in the previously purely eukaryotic SNF2 family suggests a defined subgroup of DNA helicases present in all species, with specific function in transcription activation.
MeSH terms
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Adenosine Triphosphatases
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Amino Acid Sequence
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Animals
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Bacillus cereus / genetics
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Bacillus cereus / metabolism*
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DNA Helicases / genetics*
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DNA-Binding Proteins / genetics*
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Databases, Factual
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Fungal Proteins / genetics
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Genes, Fungal
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Humans
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Molecular Sequence Data
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Multigene Family
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Nuclear Proteins*
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Open Reading Frames
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Phylogeny
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae Proteins
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Sequence Homology, Amino Acid
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Trans-Activators / genetics*
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Transcription Factors / genetics*
Substances
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DNA-Binding Proteins
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Fungal Proteins
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Nuclear Proteins
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SMARCA1 protein, human
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SMARCA2 protein, human
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Saccharomyces cerevisiae Proteins
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Trans-Activators
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Transcription Factors
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Adenosine Triphosphatases
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SMARCA4 protein, human
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SNF2 protein, S cerevisiae
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DNA Helicases