Abstract
Case report of the appearance of a highly malignant cerebral non-Hodgkin's lymphoma of a diffuse large cell type, type B, occurring at the immediate onset of chemotherapy for a stage IV (mediastino-pulmonary) Hodgkin's disease (nodular sclerosis) diagnosed in a 16-year-old boy. The treatment of this cerebral lymphoma associated primary chemotherapy with high dose methotrexate, high dose aracytine, etoposide, and ifosfamide. The chemotherapy proved to be highly efficient, producing complete remission. Thoracic and abdominal irradiation for Hodgkin's disease was performed concomitantly with chemotherapy for the non-Hodgkin's lymphoma. This treatment was followed by 36 Gy of cerebral irradiation. Thirty-six months after the discovery of the cerebral non-Hodgkin's lymphoma the patient was still disease-free and doing well.
MeSH terms
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Adolescent
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Biopsy
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Brain Neoplasms / diagnosis*
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Brain Neoplasms / drug therapy
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Brain Neoplasms / radiotherapy
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Carmustine / administration & dosage
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Cyclophosphamide / administration & dosage
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Doxorubicin / administration & dosage
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Hodgkin Disease / drug therapy*
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Hodgkin Disease / radiotherapy
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Humans
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Ifosfamide / administration & dosage
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Lymphoma, Non-Hodgkin / diagnosis*
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Lymphoma, Non-Hodgkin / drug therapy
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Lymphoma, Non-Hodgkin / radiotherapy
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Male
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Methotrexate / administration & dosage
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Neoplasms, Second Primary
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Prednisone / administration & dosage
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Procarbazine / administration & dosage
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Tomography, X-Ray Computed
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Vincristine / administration & dosage
Substances
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Procarbazine
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Carmustine
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Ifosfamide
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Prednisone
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Methotrexate