Abstract
Antibody response to antigen A60 (a mycobacterial antigen) was evaluated in ELISA in 18 HIV+ subjects with clinical and cultural evidences of mycobacterial infections, in 10 HIV+ subjects without Mycobacterial infections and in 22 healthy donors. We found higher levels of specific IgG in the HIV+ patients with Mycobacterial infections (mean 179.2 +/- 83 U) compared to the values of the donors (mean 92.5 +/- 35.5 U: p < 0.01). This test may be useful in the diagnosis of tuberculosis, but it needs clinical validation.
MeSH terms
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AIDS-Related Opportunistic Infections / complications
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AIDS-Related Opportunistic Infections / diagnosis*
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AIDS-Related Opportunistic Infections / microbiology
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Antibodies, Bacterial / blood*
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Antibodies, Bacterial / immunology
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Antigens, Bacterial / immunology*
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Enzyme-Linked Immunosorbent Assay*
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HIV Seropositivity / complications*
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Humans
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Immunoglobulin G / analysis*
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Membrane Glycoproteins / immunology*
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Mycobacterium Infections / complications
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Mycobacterium Infections / diagnosis*
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Mycobacterium Infections / microbiology
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Mycobacterium Infections, Nontuberculous / complications
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Mycobacterium Infections, Nontuberculous / diagnosis
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Mycobacterium Infections, Nontuberculous / microbiology
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Mycobacterium tuberculosis / immunology
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Mycobacterium tuberculosis / isolation & purification*
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Tuberculosis, Pulmonary / complications
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Tuberculosis, Pulmonary / diagnosis
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Tuberculosis, Pulmonary / microbiology
Substances
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Antibodies, Bacterial
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Antigens, Bacterial
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Immunoglobulin G
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Membrane Glycoproteins
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mycobacterial A60 antigen