IgG and IgA classes of anti-neutrophil cytoplasmic autoantibodies in a 13-year-old girl with recurrent Henoch-Schonlein purpura

J J Lin; C L Stewart; F J Kaskel; R N Fine

doi:10.1007/BF00864379

IgG and IgA classes of anti-neutrophil cytoplasmic autoantibodies in a 13-year-old girl with recurrent Henoch-Schonlein purpura

Pediatr Nephrol. 1993 Apr;7(2):143-6. doi: 10.1007/BF00864379.

Authors

J J Lin¹, C L Stewart, F J Kaskel, R N Fine

Affiliation

¹ Department of Pediatrics, State University of New York, Stony Brook 11794.

PMID: 8476705
DOI: 10.1007/BF00864379

Abstract

We describe a 13-year-old girl with recurrent Henoch-Schonlein purpura whose symptoms were precipitated by upper respiratory tract infections. Her serum was positive for both IgG and IgA classes of anti-neutrophil cytoplasmic autoantibodies by immunofluorescence. The titers of both autoantibodies correlated with disease activity. The immunopathology underlying these findings is discussed.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Antibodies, Antineutrophil Cytoplasmic
Autoantibodies / analysis*
Biomarkers / analysis
Female
Fluorescent Antibody Technique
Humans
IgA Vasculitis / immunology*
IgA Vasculitis / pathology
Immunoglobulin A / analysis*
Immunoglobulin G / analysis*
Recurrence
Vasculitis / immunology

Substances

Antibodies, Antineutrophil Cytoplasmic
Autoantibodies
Biomarkers
Immunoglobulin A
Immunoglobulin G