In April 1992, the National Surgical Adjuvant Breast and Bowel Project and the National Cancer Institute launched the Breast Cancer Prevention Trial. This is the largest cancer prevention trial ever attempted. The Breast Cancer Prevention Trial will involve 16,000 high-risk women in the United States and Canada. Half will receive tamoxifen and half placebo. Currently, over 5,000 women have been enrolled in the Breast Cancer Prevention Trial. The Ochsner Community Clinical Oncology Program in New Orleans is coordinating the trial in Louisiana and Mississippi. Other participating centers in this area are located in Baton Rouge, Houma, and New Orleans East in Louisiana, and Biloxi, Gulfport, Hattiesburg, and Jackson in Mississippi.