Absence of linkage between chromosome 21 loci and familial amyotrophic lateral sclerosis

A King; H Houlden; J Hardy; R Lane; A Chancellor; J de Belleroche

doi:10.1136/jmg.30.4.318

Absence of linkage between chromosome 21 loci and familial amyotrophic lateral sclerosis

J Med Genet. 1993 Apr;30(4):318. doi: 10.1136/jmg.30.4.318.

Authors

A King¹, H Houlden, J Hardy, R Lane, A Chancellor, J de Belleroche

Affiliation

¹ Department of Biochemistry, Charing Cross and Westminister Medical School, London.

Abstract

Familial amyotrophic lateral sclerosis (FALS) has recently been shown to be linked to chromosome 21 markers in a subset of families. However, we were unable to show linkage between FALS and chromosome 21 markers which flank the putative FALS locus in UK families.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amyotrophic Lateral Sclerosis / genetics*
Chromosomes, Human, Pair 21*
Genetic Linkage
Genetic Markers
Humans
United Kingdom

Substances

Genetic Markers