Abstract
Six human pituitary adenoma cultures, characterized for estrogen and progesterone (Pg) receptors, were treated with 17 beta-estradiol (17 beta-E2), Pg and tamoxifen (TAM) at different concentrations, alone and in combination, for 2, 4 and 8 days. Cell proliferation data showed in most cases a stimulating effect of 17 beta-E2 and an inhibitory effect of Pg on cell growth, which appeared to be correlated with specific receptor expression, but independent of pituitary cell hormone content. A marked inhibitory effect of TAM on cell proliferation was present in all cases, but, on the contrary, was independent of estrogen receptor expression.
MeSH terms
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Adenoma / drug therapy*
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Adenoma / metabolism
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Adenoma / pathology
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Analysis of Variance
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Cell Division / drug effects
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Estradiol / pharmacology
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Estradiol / therapeutic use*
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Growth Hormone / biosynthesis
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Humans
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Pituitary Neoplasms / drug therapy*
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Pituitary Neoplasms / metabolism
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Pituitary Neoplasms / pathology
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Progesterone / pharmacology
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Progesterone / therapeutic use*
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Prolactin / biosynthesis
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Prolactin / blood
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Prolactinoma / drug therapy
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Prolactinoma / metabolism
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Prolactinoma / pathology
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Receptors, Estrogen / biosynthesis
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Receptors, Progesterone / biosynthesis
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Tamoxifen / pharmacology
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Tamoxifen / therapeutic use*
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Tumor Cells, Cultured
Substances
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Receptors, Estrogen
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Receptors, Progesterone
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Tamoxifen
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Progesterone
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Estradiol
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Prolactin
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Growth Hormone