Abstract
Several tricyclic benzothiazines and benzothiazepines have been synthesized by different intramolecular cyclization reactions. Their functionalization led to biologically active compounds. Some stereochemical aspects as well as biological responses have been outlined.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Cyclization
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Humans
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Leukemia L1210 / drug therapy
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Leukemia, Lymphoid / drug therapy
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Mice
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Molecular Conformation
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Thiazepines / chemical synthesis*
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Thiazepines / pharmacology
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Thiazines / chemical synthesis*
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Thiazines / pharmacology
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Tumor Cells, Cultured
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Antineoplastic Agents
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Thiazepines
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Thiazines